Claudiu T. Supuran

Claudiu T. Supuran is professor of medicinal and pharmaceutical chemistry at the University of Florence, Italy, since 1995. He was a visiting professor in various universities in Australia, Argentina, Brasil, Egypt, USA, and other countries.

For over three decades his research was mainly dedicated to the metalloenzyme carbonic anhydrase, which is involved in many physiologic and pathologic processes. Other research interests include the medicinal chemistry/biochemistry of other enzymes, among which metalloproteinases, serine proteases, bacterial/viral enzyme, etc. In these fields he has made contributions to the characterization of many such new enzymes and in the design of many novel classes of inhibitors and activators, deciphering their mechanism of action at molecular level, the discovery of a new genetic family of carbonic anhydrases (-carbonic anhydrase), of new carbonic anhydrase isoforms and their role in disease (cancer, obesity, epilepsy, neuropathic pain, arthritis, cerebral ischemia, infectious diseases).

He discovered many such enzymes in various species of bacteria, fungi, corals, sponges, nematodes, vertebrates, and other organisms. Other research interests include X-ray crystallography of enzymes in complex with inhibitors/activators, pharmacological aspects of enzyme inhibitors, and others. One of the sulfonamide carbonic anhydrase inhibitors discovered in his laboratory is currently in Phase II clinical trials for the management of metastatic, hypoxic tumors.

CT Supuran has a H index of 170 (Google Scholar), he has published more than 2300 papers and 15 books in these fields. He is Editor‐in‐Chief of many journals, among which of Expert Opinion on Therapeutic Patents, Current Enzyme Inhibition, International Journal of Molecular Sciences.